sugar code on cells

In an earlier blog The Demon in the Machine Paul Davies in his book by the same name asserts that there is heightened electrical activity in embryogenesis and in cancer cells.

An article in New Scientist entitled “We could kill cancer cells by hijacking their odd electrical current” tells us that cancer cells have tPMET (Trans-Plasma Membrane Electron Transfer) that is different from normal cells.

All biological cells use electrons to power themselves. In the early 2000s, however, it was discovered that cells can also send electrons outside their membranes along biological “relays” made of proteins and other molecules. The significance of this trans-plasma membrane electron transfer (tPMET) is not known, however it’s long been suspected that there is a link between the way cancer cells change their metabolism to spread and grow and changes to the way the cells do this trans-plasma electron transfer.

It is believed that this tPMET involves phosphorylation of sugars such as glucose. Another earlier blog The Science Delusion tells us of a discovery that our cells use a sugar code more complex than DNA to identify and interact with each other. It turns out that every type of cell in our bodies has a unique sugar coating. And whenever anything interacts with a cell, it must recognise that sugar code and use the appropriate secret handshake. The sugar code, known as the glycome, contains tens of different sugars that fit together in branched strings called glycans. Reading the sugar code isn’t just a case of decoding it letter by letter, but recognising the shape of each sugar and understanding what it means. The things that latch on to cell surface sugars in nature – the hands that do the grabbing – are proteins called lectins, which have internal cavities that fit snugly around specific sugars.

What we see here is a classic case of scientists talking about the same thing in different ways. One group of scientists are calling it tPMET and another group are calling it a chemical recognition of the sugar code. The fact is that these sugars on the outside of the cell are soluble and the cell in vivo is immersed in water. These sugars on the outside of the cell membrane create an electron rich liquid medium that is excellent for the conduction of electricity. Just like the sugar-phosphate backbone of the DNA that is hydrophilic and also soluble in water that creates an electron rich liquid medium for the conduction of electricity.

The living cell in vivo is an extremely complex electronic unit and any attempt to describe it in terms of ‘chemical reactions’ or even in terms of ‘chemoelectricity’ or ‘bioelectricity’ is simply missing the point. All communication in cells, whether intracellular or extracellular, takes place as a result of tuning into precise frequencies in the EMF (Electromagnetic Force) aka electronics aka EMR (Electromagnetic Radiation) aka biophotons aka optogenetics aka radiogenetics aka magnetogenetics.

Scientists from Sydney’s Garvan Institute of Medical Research have announced that the glycoprotein perlecan is involved in the fast spreading of pancreatic cancer. They hail this as some sort of breakthrough in cancer research. What they don’t seem to realize is that Glycoproteins are frequently present at the surface of cells where they function as membrane proteins or as part of the extracellular matrix. These cell surface glycoproteins play a critical role in cell–cell interactions and the mechanisms of infection by bacteria and viruses and cancers. Perlecan is hydrophilic and some of its domains are actually soluble in water. Perlecan is on the surface of cells and in the extracellular matrix and the modules of perlecan are connected like cars into one long diverse complex train. In other words the primary function of perlecan is the conduction of electricity for cell-to-cell communication and what’s more because it’s the water that is responsible for the conductivity it is conducting an alternating current (AC). In other words the electricity that is being conducted is giving off ELF radiowaves aka brainwaves. See CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications, 2019; 10 (1) https://www.nature.com/articles/s41467-019-10968-6

GUT BACTERIA IS ALSO ENGAGED IN ELECTRON TRANSFER

Meanwhile another breakthrough research paper has found that poo transplants choke tumors. The researchers showed that faecal microbiota transplants (FMT) from long-term human survivors prompted an immune response and stifled tumours. This is the latest and somewhat startling example of gut health playing a powerful part in treating challenging conditions. Maybe they should take a look at an article in ScienceDaily: Gut bacteria’s shocking secret: They conduct electricity. “To date, most electricity-generating bacteria have come from weird environments, but researchers have found more than 100 in the human microbiome, both pathogenic and probiotic. They were unsuspected because they employ a different and simpler extracellular electron transfer system, which may prove useful in creating bacterial batteries. Their electrogenic ability may be important in infectivity, or in how they ferment cheese and yogurt.” https://www.sciencedaily.com/releases/2018/09/180912133442.htm#targetText=Gut%20bacteria's%20shocking%20secret%3A%20They%20produce%20electricity&targetText=Summary%3A,microbiome%2C%20both%20pathogenic%20and%20probiotic

There is any number of research papers in the literature that electrical stimulation induces c-Fos proto-oncogene expression which is widely believed to be involved in cancer because it is responible for normal cell proliferation. See for example:  Distribution of preganglionic terminals in the cervical sympathetic ganglia detected by the expression of c-Fos like protein after electric stimulation of the ventral root. Asamoto K , Tamamaki N , Nojyo Y Kaibogaku Zasshi. Journal of Anatomy [01 Jun 2001, 76(3):303-311]

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